About IUI

Question : What is IUI? When should one do it?

Answer : IUI involves placing sperm inside a woman’s uterus after ovulation to facilitate fertilization. In today’s time the following scenarios might require it:

  • Unexplained infertility for less than five years.
  • Anovulatory cycle which includes irregular menstruation.
  • Male sub-fertility having more than 10 million counts.
Question : What’s the percentage of successful results in IUI?
Answer : Evidence based medicine suggests that in case of IUI, the results do not increase more than 18-20%.
Question : How many times can IUI procedure be repeated ?
Answer : IUI procedure should not be conducted more than three times. Else, it may affect the ovarian reserve which may eventually lead to negative outputs in case of IVF attempts. Moreover, it has been proven in the medical literature that it is not cost-effective to do IUI more than three times as chances of success after three attempts of IUI are very slim. If IUI would really help a couple conceive, the results are mostly seen in the first three attempts itself. So it is not advisable to keep trying IUI when three or more attempts with IUI have already failed.
Question : What can one expect in an IUI cycle?
Answer : Intra-uterine insemination is basically inducing ovulation with oral tablets or injections, assisting rupture of one or two mature follicles and inserting healthy, motile sperms from the husband in uterine cavity. Results are best when gonadotropin injections are given for folliculogenesis and when the patient selection is appropriate.
Question : When should one avoid IUI?

Answer :

  • In case of male infertility cases with less than 10 million count and less than 10% motility.
  • Less than 4% morphology in semen analysis.
  • AMH levels less than 2.5 in female partner.
  • Age of more than 35 years of female partner and infertility period more than 10 years.
  • When both tubes are blocked.
  • Moderate to serve endometriosis. In above case, IVF is the choice of treatment.